GENE EXPRESSION REGULATION TECHNOLOGY AND NONCODING RNAS FOR DIAGNOSIS AND THERAPY

摘要

A nucleic acid molecule comprising sequentially: a 7SL small-RNA derived sequence comprising at least the binding domain to srp9 and srp14 proteins of the 7SL ribonucleocomplex; a sequence identical or complementary to a target sequence; a pol III type III promoter; and derivatives thereof for medical and diagnostic use.