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THE BIOMARKERS FOR DIAGNOSIS OF HEPATOTOXICITY INDUCED BY BENZENE AND THE METHOD OF DIAGNOSIS FOR HEPATOTOXICITY THEREOF
THE BIOMARKERS FOR DIAGNOSIS OF HEPATOTOXICITY INDUCED BY BENZENE AND THE METHOD OF DIAGNOSIS FOR HEPATOTOXICITY THEREOF
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机译:苯引起的肝毒性诊断的生物标志物及其诊断方法
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摘要
PURPOSE: A biomarker for diagnosing hepatotoxicity induced by benzene and a method for diagnosing hepatotoxicity are provided to study mechanism of hepatotoxicity and leukemia induced by exposure of benzene and other various chemicals. CONSTITUTION: A biomarker for diagnosing hepatotoxicity induced by benzene is a gene of which expression is increased or decreased by exposure of a hepatotoxicity chemical. The hepatotoxicity chemical is benzene. A method for diagnosing hepatotoxicity comprises: a step of isolating RNA from hepatocytes of experimental group of patient and control group; a step of synthesizing cDNA of the experimental group and control group; a step of synthesizing cDNA to cRNA a step of hybridizing using cRNA with microarray; a step of analyzing microarray; and a step of comparing results of control group and experimental group.
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