MUTATED P53 PROTEIN CAPABLE OF BEING USED AS A NEW CANCER TREATMENT MEDICINE, A TARGET PROTEIN FOR THE DEVELOPMENT OF A NEW CANCER TREATMENT, AND A SCREENING METHOD OF AN ANTI-CANCER MATERIAL USING THEREOF

摘要

PURPOSE: A mutated p53 protein capable of being used as a target protein for the development of a new cancer treatment and a screening method of an anti-cancer material using thereof are provided to induce the activation of a STAT3 protein.;CONSTITUTION: A mutated p53 protein contains an amino acid sequence of the sequence number 2. The mutated p53 protein includes a controlling function of an apoptosis at a thyroid indifferent cancer cell. The mutated p53 protein induces activation or the development of a STAT3 protein to control the apoptosis. A screening method of an anti-cancer material using the mutated p53 protein comprises the following steps: preparing an in-vitro system including the mutated p53 protein and an anti-cancer candidate material; contacting the anti-cancer candidate material and the p53 protein; and determining whether the p53 protein and the anti-cancer candidate material are interacting.;COPYRIGHT KIPO 2010