Method for screening anti-cancer material using mutant ?53 protein having gain-of-function which is a target protein as a mediator related to the suppression of cancer

摘要

Mutant p53 protein of the invention is a target protein as a cancer-related inhibitory agent. Mutant p53 proteins of the present invention has a function to suppress the induced cell death as a function acquiring sex mutant protein, a STAT3 protein expression induction or activation of the STAT3 protein. Specifically, the mutant p53 protein of the present invention inhibit the cell death through activation STAT3 protein. With the mutant p53 protein of the present invention can develop effective cancer therapy or cancer therapy. According to the invention, wherein for cancer-cell mutant p53 protein having apoptotic function anticancer candidate key target protein as a utilization point complex, yet comprehensive action more than STAT3 using controlled in the previous stage high STAT3 expression and activity of a substance It may screen for an antitumor substance and to analyze its performance. ; Anaplastic thyroid cancer, p53 mutations, mutation function acquired gender, Miss sense mutations, glycine, valine, apoptosis inhibition, the target protein, the cancer therapeutic screening, STAT3 activation