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COMPLEXES BETWEEN AN AMPHIPHILIC POLYMER AND AN OSTEOGENIC PROTEIN OF THE BMPS FAMILY
COMPLEXES BETWEEN AN AMPHIPHILIC POLYMER AND AN OSTEOGENIC PROTEIN OF THE BMPS FAMILY
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机译:BMPS家族的两亲性聚合物和骨形成蛋白之间的复合物
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摘要
The invention relates to a physically and chemically stable, water-soluble amphiphilic polymer-BMP complex, characterised in that: the amphiphilic polymers include a hydrophilic polysaccharide skeleton functionalised by hydrophobic substituants and hydrophilic groups; the BMP is selected from the group of therapeutically active BMPs (Bone morphogenetic Proteins); the polymer/BMP mass ratio is lower than or equal to 700. The invention also relates to a method for preparing the amphiphilic polymer-BMP complex in an aqueous medium in the absence of any solvent capable of denaturing the protein. The invention further relates to therapeutic compositions of the amphiphilic polymer-BMP complex of the invention.
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