METHOD FOR MANUFACTURING MAGNESIUM SALT OF CHENODEOXYCHOLIC ACID AND URSODEOXYCHOLIC ACID

摘要

PURPOSE: A method for manufacturing magnesium salt of chenodeoxycholic acid and ursodeoxycholic acid is provided to prevent or treat cholelithiasis. CONSTITUTION: A method for manufacuting magnesium salt of chenodeoxycholic acid and ursodeoxycholic acid of chemical formula 3 comprises: a step of dissolving chenodeoxycholic acid of chemical formula 1 and ursodeoxycholic acid of chemical formula 2 and adding alkali(first group) hydroxide of sodium hydroxide(NaOH), potassium hydroxide(KOH) or lithium hydroxide(LiOH); a step of adding magnesium chloride(MgCl_2) and stirring; a step of cooling and filtering chloride salt to remove organic solvent; and a step of refluxing in acetone.