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CONTROLLED-RELEASE ACECLOFENAC CONTAINING ORAL DRUG PREPARATIONS AND IT'S MANUFACTURING PROCESS
CONTROLLED-RELEASE ACECLOFENAC CONTAINING ORAL DRUG PREPARATIONS AND IT'S MANUFACTURING PROCESS
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机译:含口服药物的控释醋氯芬酸及其制备工艺
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摘要
PURPOSE: An aceclofenac-containing sustained release tablet is provided to control release and to promote absorption and stability of aceclofenac absorption. CONSTITUTION: An aceclofenac sustained release tablet comprises: an immediate release layer containing aceclofenac, water soluble additive, pH adjuster, disintegrant, filler and lubricant; and a sustained release layer containing aceclofenac, release control polymer, fat soluble surfactant, filler, and lubricant. The pH adjuster is sodium hydrogen carbonate. The release control polymer is a mixture of hydroxypropylmethyl cellulose and carbomer in a mixture ratio of 10:1-20:1. The water soluble additive is poloxamer.
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