THE BIOMARKERS FOR DIAGNOSIS OF REPRODUCTIVE TOXICITY INDUCED BY BISPHENOL A AND THE METHOD FOR DIAGNOSIS THEREOF

摘要

PURPOSE: A biomarker for diagnosing reproductive toxicity induced by bisphenol A is provided to identify mechanism of productive toxicity by bisphenol A exposure. CONSTITUTION: A biomarker for diagnosing reproductive toxicity induced by bisphenol A(BPA) contains a gene of which expression is changed by bisphenol A exposure. The expression of the gene is increased or decrease by bisphenol in 10~50 mg/kg weight(light). A microarray chip for diagnosing reproductive toxicity induced by bisphenol A contains an entire nucleic acid sequence of biomarker gene; oligonucleotide; or complementary strand thereof. A method for detecting the biomarker comprises: a step of labeling cDNA of experimental group and control group with different fluorescence; a step of hybridizing the cDNA with the DNA microarray chip; a step of analyzing the DNA microarray chip; and a step of comparing expression level.