COMPOSITION FOR PREVENTION AND TREATMENT OF LUNG CANCER CONTAINING MUTANT OR EXPRESSION INHIBITOR OF OSTEOPONTIN

摘要

PURPOSE: A mutant or inhibitor of osteopontin is provided to prevent and treat lung cancer. CONSTITUTION: An osteopontin mutant has residues in which Thr118, Thr122, Thr127, Thr131 or Thr136 is substituted with alanine. A composition for preventing and treating lung cancer contains the osteopontin mutant. The composition is formulated in an aerosol gene delivery. A composition for preventing and treating lung cancer contains an antisense molecule to osteopontin gene. The antisense molecule is shRNA having nucleotide of sequence numbers 7 and 8.