SiRNA for inhibiting expression of porcine GGTA1 and an expression vector comprising same

摘要

The present invention provides an siRNA capable of effectively inhibiting the expression of the porcine gene alpha-1,3-galactosyl transferase (GGTA1), which causes a fatal immune rejection reaction in humans when transplanting between different organs. It provides an expression vector comprising the siRNA, and a method of producing a cloned pig that can reduce the acute immune rejection reaction comprising transforming the expression vector comprising the siRNA.;Xenotransplantation, siRNA, GGTA1, Acute Immune Rejection