An used of the Joule heating to make biocompatible heat condition in fully integrated micromachined magnetic cell sorting system

摘要

The present invention is a silicon substrate and a microfluidic channel on the electromagnet for separation of cells labeled with magnetic particles relates to an integrated chip device for cell separation, as in more detail is a microfluidic channel and a cell separation apparatus using magnetic field, which is in the form of chips, the use of the electromagnet, do not damage the cell sample, using the Joule heat relates to the cells in the fluid temperature in the injection channel as cell sorting chip device for maintaining the proper temperature of the cell viability. ; magnetic cell separation apparatus of the present invention is a silicon wafer; Located at the top of the silicon wafer, the cell contains a sample flow channel portion for the microfluidic channels to be injected; Located at the bottom of the silicon wafer, electromagnetic portion for generating a magnetic field necessary to induce cell sorting; and characterized in that it comprises a ; The electromagnet coil conductor portion, an insulating layer, made of ferromagnetic material and provided with a plate jimyeo, the flow channel section is achieved by having a microfluidic channel and a cooling channel.