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HUMANIZED ANTIBODY SPECIFIC FOR HUMAN TUMOR NECROSIS FACTOR-?
HUMANIZED ANTIBODY SPECIFIC FOR HUMAN TUMOR NECROSIS FACTOR-?
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机译:人体肿瘤坏死因子特异性人源化抗体?
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摘要
Humanized antibodies specifically binding to hTNF-alpha are prepared from a mouse monoclonal antibody by the CDR (complementarity determining region) grafting method, and they show an antigen binding affinity similar to the original mouse monoclonal antibody and significantly low immunogenicity. Therefore, the humanized antibodies can be effectively used for treating a hTNF-alpha-related disease such as rheumatoid arthritis, Crohn's disease, psoriatic arthritis, psoriasis, septicemia, asthma, Wegener's granulomatosis, inflammation, and ankylosing spondylitis.
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