Novel spirochromene-2,4'-piperidine thiourea derivatives or pharmaceutically acceptable salt thereof, preparation method and pharmaceutical composition for the modulation and treatment of multidrug resistance containing the same as an active ingredient

摘要

The present invention relates to a spy represented by the formula [chromene -2,4'- piperidin- din] thio acceptable salt urea derivative or a pharmaceutically, relates to a pharmaceutical composition for the control or treatment of multidrug resistance in cancer, and methods for their preparation containing the same as an active ingredient, a derivative of the invention is P- glycoprotein overcoming the multi-drug resistance to anti-cancer agents by inhibiting the over-expression, can treat or control, and to increase the anti-cancer agents and anti-cancer activity when administered in combination may improve the survival rate of cancer patients, by reducing the amount of anticancer agent administered in combination provides an effect capable of reducing the side effects on normal cells. ; [Formula 1] ; (R ¹ and R ² is defined in the specification as shown)