Novel 2-alkoxymethyl-2-methyl-6-ureido benzopyran derivatives or pharmaceutically acceptable salt thereof, preparation method thereof and pharmaceutical composition for the modulation and treatment of multidrug resistance containing the same as an active ingredient

摘要

The invention relates to formula (I) to show that 2-alkoxy-methyl-2-methyl-6 - Fig yureyi benzopyran derivative or pharmaceutically acceptable salt thereof, to a pharmaceutical composition for the control or treatment of multidrug resistance in cancer, and methods for their preparation containing the same as an active ingredient. Derivative of the general formula (I) according to the present invention is to suppress the over-expression of P- glycoprotein overcome multidrug resistance in cancer therapy or can be adjusted, and the anti-cancer activity when administered in combination to increase the survival rate of cancer patients with cancer and it may increase, by reducing the amount of anticancer agent administered in combination can provide an effect capable of reducing the side effects on normal cells. ; [Formula 1] ; (R ¹ and R ² are as defined in the Statement)