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A NOVEL GENE FROM HANCENULA POLYMORPHA CAPABLE OF CONTROLLING UNFOLDED PROTEIN RESPONSE AND METHOD FOR INCREASING EFFECT OF SECRETION USING THE SAME
A NOVEL GENE FROM HANCENULA POLYMORPHA CAPABLE OF CONTROLLING UNFOLDED PROTEIN RESPONSE AND METHOD FOR INCREASING EFFECT OF SECRETION USING THE SAME
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机译:能够控制未折叠蛋白质反应的汉氏多角藻新基因及其使用该方法增加分泌作用的方法
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摘要
the present invention is to regulate the secretion of stress responses to poly-century nulra Maurepas ( Hancenula polymorpha by using the novel gene and the gene of ) according to a method of increasing the secretion efficiency of recombinant protein expression, the more specifically a century nulra core control of UPR (Unfolded Protein Response) mechanism in poly Maurepas factor HpHAC1 gene and its identification by the control mechanism, and by this operation, and use a method to increase the expression efficiency of recombinant protein secretion. According to ; This invention, by using a poly century nulra Maurepas secretion expression systems, by mass production to a secretory protein for industrial or medical use, to obtain the economics of producing a large amount of protein at a lower cost can. Accordingly, the invention is applicable when a protein pharmaceutical industrially useful at the same time, to produce a pharmaceutical protein at low cost and economic ease the burden on the patient can contribute to human health and welfare of a zoom.
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