CAPTURE OF PRE-ENDOTHELIAL CELLS BY ELECTING MEDICINES IMPLANTED BY A MEDICAL DEVICE

摘要

1. An implantable medical device having a luminal surface and a coating, characterized in that the coating contains one or more layers of a non-polymer or polymer matrix, one or more pharmaceutical substances and a ligand attached to this matrix and designed to capture circulating precursor cells on the luminal surface the specified device after implantation of the specified medical device to the patient. ! 2. The implantable medical device according to claim 1, characterized in that the medical device is a stent, a vascular graft, a synthetic graft, a heart valve, a catheter, a vascular prosthetic filter, a pacemaker, a pacemaker, a defibrillator, a septum device to close an open oval window, vascular clip, occluder for correcting vascular aneurysm, transplant for hemodialysis, catheter for hemodialysis, atrioventricular shunt, device or component transplant grafts for correction of aortic aneurysm, venous valve, transducer, suture, clips of a vascular anastomosis, a venous or arterial catheter permanently inside, a vaginal vagina and a drug delivery channel. ! 3. The implantable medical device according to claim 1, characterized in that the non-polymer matrix is made of a porous material containing nanoparticles. ! 4. The implantable medical device according to claim 3, characterized in that the nanoparticles are made of metal or a metal alloy. ! 5. The implantable medical device according to claim 1, characterized in that the ligand is selected from the group consisting of