METHODS FOR FORECASTING AND PREDICTION OF CANCER AND MONITORING THERAPY OF CANCER DISEASES

摘要

1. A method for monitoring the condition of a disease associated with a VEGF pathway in a patient and / or monitoring how a patient with the specified disease responds to therapy involving immunological detection and quantitative analysis of successive changes in VEGF protein levels in patient samples taken over time where increasing levels of VEGF protein over time indicate disease progression or an adverse reaction to the indicated therapy, and where decreasing levels of VEGF protein over time indicate rem ssiyu disease or positive response to said therapy. ! 2. The method according to claim 1, where the specified therapy is selected from multikinase inhibitors, tyrosine kinase inhibitors, monoclonal antibodies and bis-arylureas. ! 3. The method according to claim 1, where the specified therapy is aimed at the path of VEGF therapy. ! 4. The method according to claim 3, wherein said pathway-directed VEGF therapy is a tyrosine kinase inhibitor imatinib mesylate or bis-arylurea Sorafenib. ! 5. The method according to claim 1, wherein said patient samples are selected from the group consisting of blood, serum, plasma, urine, saliva, seminal fluid, exudate from the breast, cerebrospinal fluid, tear, sputum, mucus, lymph, cytosols, ascites, pleural effusions, amniotic fluid, flushing fluid of the bladder and bronchoalveolar lavage. ! 6. The method according to claim 5, where the specified sample taken from the patient is serum or plasma. ! 7. The method according to claim 1, where the specified immunological detection and quantitative analysis is carried out using immunoassay in the form of a sandwich ELISA or equivalent analysis. ! 8. The method according to claim 7, where the sandwich ELISA or ec