NEW N-SULFAMOIL-N-BENZOPYRANIPIPERIDINES, INTENDED FOR USE IN MEDICINE

摘要

1. The compound of formula I! ! wherein ! R1 and R2 are independently selected from the group consisting of hydrogen, C1-C4 alkyl, C4-C7 cycloalkyl, or! R1 and R2 together form a 5- or 6-membered ring, which optionally may contain from 1 to 2 heteroatoms independently selected from the group consisting of nitrogen and / or oxygen atoms, and which may also be substituted by optionally substituted aryl, optionally substituted heteroaryl or arylenehaloalkyl; ! R3 to R6 are independently selected from the group consisting of hydrogen; halogen; C1-C4 alkyl; C2-C4 alkenyl optionally substituted with aryl; C1-C4 alkoxy group; ! A C1-C4 alkoxy group substituted with a halogen, provided that the alpha carbon atom, if substituted, is not substituted with a halogen other than fluorine; C2-C4 alkynyl; C1-C4-NSO2 alkyl; NH2; NO2; C1-C4 aminoalkyl; C2-C8 aminodialkyl; cyano group; oxyaryl; oxyalkylenearyl; hydroxyarylenalkyl; hydroxyalkylene arylenealkoxy; ! C2-C8 ester group; C1-C8 amido group; C2-C8oxyalkylenecarbonylalkyl; C2-C8oxyalkyleneoxyalkyl; C1-C4 amidooxyalkyl; aryl optionally substituted; heteroaryl optionally substituted; fused aryl optionally substituted; fused heteroaryl, optionally substituted, or! R3 and R6 have the same meanings as above, and in which R4 and R5 together form a 5- or 6-membered ring, which optionally may contain from 1 to 3 heteroatoms independently selected from the group consisting of nitrogen, oxygen and sulfur, and which optionally may contain 1 or 2 double bonds, and which may also contain a carbonyl group, and which may also be substituted with C1-C4 alkyl, C1-C4 haloalkyl, optionally substituted aryl and / or not