METHOD FOR PRODUCING EPOTHYLONE DERIVATIVES, NEW EPOTHYLON DERIVATIVES, AND ALSO NEW INTERMEDIATE COMPOUNDS FOR IMPLEMENTATION OF THE METHOD AND METHODS FOR PRODUCING THEM

摘要

1. The compounds of formula 9! ! where R1 is methyl, a R2 is unsubstituted or substituted aryl, and salts with metal cations. ! 2. The compounds of formula 9! ! where R1 is methyl, a R2 is unsubstituted or substituted phenyl, and salts with metal cations. ! 3. The compounds of formula 3! ! where R2 has the meanings given in the definition of formula 9.! 4. A method of obtaining compounds of formula 3, characterized in that the compound of formula 1,! where R2 has the meanings indicated above, and the mesyl group in all subsequent reactions is replaced by tosyl and a similar group, interacts with the sultam derivative of formula 2 in all subsequent stages of the reaction, for example,! ! in the reaction of selective aldol condensation in the presence of a Lewis acid and with the addition of a base in an inert solvent at a reduced temperature from -50 ° C to -100 ° C, and then at an elevated temperature from -20 ° C to 20 ° C, with the formation of a compound of formula 3 .! 5. The compounds of formula 4! ! where R2 has the meanings indicated above. ! 6. A method of obtaining compounds of formula 4, characterized in that the compound of formula 3! ! interacts with the silyl ether forming compound at a temperature of from -70 ° C to 25 ° C in the presence of 2,6-lutidine to form the above compound of formula 4.! 7. The compounds of formula 5! ! where R2 has the meanings indicated above. ! 8. The method of obtaining new compounds of formula 5, characterized in that in the compounds of formula 4! ! by treatment with TBAOH / H2O2 in DME or LiO2H in THF / MeOH / H2O, the chiral auxiliary group is cleaved to form a carboxylic acid, i.e. compounds of formula 5.! 9. The compounds of formula 6! ! where R2 has the meanings indicated above. ! 10. The method of obtaining new compounds of formula 6,