METHOD FOR SYNTHESIS OF 3'-IODOFOLIC ACID AND 3'-BROMOFOLIC ACID, LABELLED WITH RADIOACTIVE ISOTOPES OF IODINE AND BROMINE

摘要

1. A process for preparing the 3 'and 3'-yodfolievoy bromfolievoy acids radiolabelled iodine or bromine atom, consists in the fact that the prepared stock solution containing folic acid, radioactive iodine or radioactive bromine in the form of iodide ion or bromide ion as the pH of this solution was approximately 7 then lower the pH of this solution to 3.5-4.9, adding to said solution an oxidizing agent from the group of chlorinated acid amides in a buffer solution. ! 2. A process for preparing the 3 'and 3'-iodfolievoy bromfolievoy acids radiolabelled iodine or bromine according to claim 1, characterized in that an oxidant from the group of chlorinated acid amides used chloramine T or chloramine B.