首页> 外国专利> COMBINATIONS OF THE ACTIVATOR (ACTIVATORS) OF THE RECEPTOR ACTIVATED BY THE PROLIFERATOR PEROXISIS (RAPP), AND THE INHIBITOR (INHIBITORS) OF SUCKING STERIN AND TREATMENT OF DISEASES OF VESSELS

COMBINATIONS OF THE ACTIVATOR (ACTIVATORS) OF THE RECEPTOR ACTIVATED BY THE PROLIFERATOR PEROXISIS (RAPP), AND THE INHIBITOR (INHIBITORS) OF SUCKING STERIN AND TREATMENT OF DISEASES OF VESSELS

机译:增殖性放热(RAPP)激活的受体激活剂(激活剂)与吸脂蛋白和血管疾病治疗的抑制剂(抑制剂)的组合

摘要

1. A composition comprising:! (a) the compound represented by formula (II) below:! ! or a pharmaceutically acceptable salt or solvate thereof,! (b) lactose monohydrate,! (c) microcrystalline cellulose,! (d) povidone! (e) croscarmellose sodium,! (f) sodium lauryl sulfate, and! (g) magnesium stearate. ! 2. The composition according to claim 1, in which the compound represented by formula (II) means:! . ! 3. The composition according to claim 1, which includes! Component Component content, wt.% Compound of formula (II) 10 Lactose monohydrate 55 Microcrystalline cellulose 20 Povidone 4 Croscarmellose sodium salt 8 Sodium lauryl sulfate 2 Magnesium stearate 1 Total 100! 4. The composition according to claim 1, which includes! Component Component content, mg Compound of formula (II) 10 Lactose monohydrate 55 Microcrystalline cellulose 20 Povidone 4 Croscarmellose sodium salt 8 Sodium lauryl sulfate 2 Magnesium stearate 1 Total 100! 5. A composition comprising:! (a) the compound represented by formula (II) below:! ! or a pharmaceutically acceptable salt or solvate thereof,! (b) lactose! (c) cellulose, and! (d) povidone. ! 6. The composition according to claim 3, which further includes croscarmellose sodium. ! 7. A therapeutic combination including:! (a) a first amount of at least one cholesterol biosynthesis inhibitor; ! (b) a second amount of the compound represented by formula (II) below:! ! or a pharmaceutically acceptable salt or solvate thereof; ! (c) lactose monohydrate,! (d) microcrystalline cellulose,! (e) povidone! (f) croscarmellose sodium salt,! (g) sodium lauryl sulfate, and! (f) magnesium stearate,! in which the first quantity and the second quantity together include
机译:1.一种组合物,其包含: (a)由下式(II)表示的化合物: !或其药学上可接受的盐或溶剂化物! (二)乳糖一水合物! (三)微晶纤维素! (d)聚维酮! (e)交联羧甲基纤维素钠! (f)月桂基硫酸钠,和! (g)硬脂酸镁。 ! 2.根据权利要求1的组合物,其中式(II)表示的化合物是指: 。 ! 3.根据权利要求1的组合物,其包括!成分成分含量,重量%式(II)化合物10一水乳糖55微晶纤维素20聚维酮4交联羧甲基纤维素钠盐8月桂基硫酸钠2硬脂酸镁1总计100! 4.根据权利要求1的组合物,其包括!组分组分含量,mg式(II)化合物10一水乳糖55微晶纤维素20聚维酮4交联羧甲基纤维素钠盐8月桂基硫酸钠2硬脂酸镁1总计100! 5.一种组合物,其包含: (a)由下式(II)表示的化合物: !或其药学上可接受的盐或溶剂化物! (二)乳糖! (三)纤维素和! (d)聚维酮。 ! 6.根据权利要求3的组合物,其进一步包含交联羧甲基纤维素钠。 ! 7.一种治疗组合,包括: (a)第一种至少一种胆固醇生物合成抑制剂; ! (b)第二量的下式(II)表示的化合物: !或其药学上可接受的盐或溶剂化物; ! (三)乳糖一水合物! (d)微晶纤维素! (e)聚维酮! (六)交联羧甲基纤维素钠盐! (g)月桂基硫酸钠,和! (f)硬脂酸镁!其中第一数量和第二数量一起包括

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