USE OF DROSPIRENONE TO PREVENT HIGH BLOOD PRESSURE IN PATIENTS WITH PREHYPERTENSION

摘要

1. The use of drospirenone for the preparation of a medicament to prevent the development of high blood pressure ( 140/90 mmHg) in a patient who is prone to developing high blood pressure. ! 2. The use according to claim 1, where the patient is a salt-sensitive patient. ! 3. The use according to claim 2, where the patient is a person. ! 4. The use according to claim 3, where the patient is a man. ! 5. The use according to claim 3, where the patient is a woman. ! 6. The use according to claim 5, together with estrogen. ! 7. The use according to claim 6, where the estrogen is selected from the group of ethinyl estradiol, mestranol, hinestranol, estradiol, estrone, estran, estriol, aestrol and conjugated horse estrogens. ! 8. The use according to claim 7, where the estrogen is estradiol. ! 9. The use according to claim 7, where the estrogen is a conjugated horse estrogen (CEE). ! 10. The use according to claim 7, where the estrogen is ethinyl estradiol. ! 11. The use according to claim 1, where the amount of drospirenone is from 0.25 to 3.0 mg, calculated on the basis of daily requirements. ! 12. The use according to claim 11, where the amount of drospirenone is from 0.25 to 3.0 mg per daily dosage unit. ! 13. The use according to claim 6, where the amount of estrogen is up to 2.0 mg of estradiol or a bioequivalent amount of another estrogen. ! 14. A method for preventing the development of high blood pressure (≥140 / 90 mmHg) in a patient who is prone to developing high blood pressure by administering drospirenone to a patient in need of such prevention. ! 15. The method according to 14, where the patient is a salt-sensitive patient. ! 16. The method according to clause 15, where the patient is a person. ! 17. The method according to clause 16, where