HETEROCYCLIC NITRIED COMPOUNDS AS ANTOTHELINE RECEPTOR ANTAGONISTS

摘要

1. The compound of General formula (I), or its pharmaceutically acceptable salt, or its stereoisomer! ! where m, m 'and m' 'are 0 or 1; ! n, n 'and n' 'are 0 or 1; ! s, s' and s' 'are 0 or 1; ! And selected from the group consisting of:! ! ! ! ! !! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! where N1 is —O—, —OH; ! N2 is —N—, —NH—; ! N3 is —C (O) O—, —C (O) NH—; ! B, B 'and B' 'are —CO—, —C (O) O—, —C (O) NH—; ! C, C 'and C' 'are! ,,; ! provided that ! 1) if A is selected from the group consisting of:! (Ia), (Ib), (Ic), (Ie), (If), (Ig), (Ih), (Ii), (Ij), (Ik), (Il) and (Im), then, at least one of m, m ′, m ″, n, n ′ or n ″ is 1; ! 2) if A is selected from the group consisting of:! (In), (Io), (Ip), (Iq), (Ir), (Is) and (Iu), then s', s' 'and m are 0; whereas n is 0 or 1; ! 3) if A is (It), then m, m 'and s'' are 0; whereas n and n 'are 0 or 1; ! 4) at least one of N1 or N2 is a group -O- or -N- capable of linking at least one of the groups - [(B) m- (C) n- (Y-ONO2)], - [(B ') m' - (C ') n' - (Y'-ONO2)] or - [(B '') m '' - (C '') n '' - (Y '' - ONO2) ]; ! Y, Y 'and Y' 'are a bivalent radical having the following properties:! a)! linear or branched C1-C20 alkylene, optionally substituted with one or more substituents selected from the group consisting of: halogen atoms, hydroxy, -ONO2 or Ta, where Ta is! -OC (O) (C1-C10 alkyl) -ONO2 or -O (C1-C10 alkyl) -ONO2; ! cycloalkene from 5 to 7 carbon atoms in the cycloalkene ring, the ring being possibly substituted with a side chain T, where T is a linear or branched alkyl of 1 to 10 carbon atoms; ! b)! ! c)! ! where n0 is an integer from 0 to 20, and n1 is an integer from 1 to 20; ! d)! ! where n1 is as defined above, and n2 is an integer from 0 to 2; X1 = —OCO— or —COO— and R2 is H or CH3; ! e)! ! where n1, n2, R2 and X1 are such as op