HETEROCYCLIC COMPOUNDS WITH ANTI-PROLIFERATING AND ANTITUMOUR ACTIVITY AND METHOD OF RETARDING SPEED OF PROLIFERATION OF TUMOR CELLS

摘要

1. A compound of formula 1 or its pharmaceutically acceptable derivatives of bis (5-metilaminometiluratsil) polymethylene! ! where n = 1-4. ! 2. A compound according to claim 1 comprising derivatives of bis (5-metilaminometiluratsil) polymethylene when n = 1! 5- [3- (2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinylmethylamino) propylaminomethyl] -1,2,3,4-tetrahydro-2,4-pyrimidinedione. ! 3. A compound according to claim 1 comprising derivatives of bis (5-metilaminometiluratsil) polymethylene when n = 2! 5- [4- (2,4-dioxo-l, 2,3,4-tetrahydro-5-pyrimidinylmethylamino) butylaminomethyl] -1,2,3,4-tetrahydro-2,4-pyrimidinedione. ! 4. A compound according to claim 1 comprising derivatives of bis (5-metilaminometiluratsil) polymethylene when n = 3! 5- [5- (2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinylmethylamino) pentylaminomethyl] -l, 2,3,4-tetrahydro-2,4-pyrimidinedione. ! 5. A compound according to claim 1 comprising derivatives of bis (5-metilaminometiluratsil) polymethylene when n = 4! 5- [6- (2,4-dioxo-l, 2,3,4-tetrahydro-5-pyrimidinylmethylamino) hexylaminomethyl] -1,2,3,4-tetrahydro-2,4-pyrimidinedione. ! 6. The process of slowing down the rate of proliferation of tumor cells, comprising administering to the environment an acceptable amount of an active compound, characterized in that as active compound a compound administered according to any of claims 1-4.