Pyridine derivatives for the treatment of metabolic disorders associated with resistance to the effects of insulin or hyperglycemia

摘要

1. The compound of General formula (I):! ! where Ar represents a phenyl group substituted by heterocyclyl or heteroaryl; where a heterocyclyl or heteroaryl group may be unsubstituted or substituted; ! B is —O—, —S— or —NH—; ! R1 represents hydrogen; ! R2 is S (O) 2R4 or C (O) (CH2) n-C (O) OR5; ! R3 is halogen, cyano, (CO) OR6 or C (O) NR7R8; ! R4 is unsubstituted or substituted aryl; ! R5 is hydrogen, (C1-C6) alkyl or unsubstituted or substituted aryl; ! R6 represents hydrogen or (C1-C4) alkyl; ! R7 and R8 independently represent hydrogen or (C1-C6) alkyl; ! n is an integer from 1 to 3; and! its stereoisomer, pharmaceutically acceptable salt or solvate. ! 2. The compound according to claim 1, where! Ar represents a phenyl group substituted with heterocyclyl; where the heterocyclyl group may be unsubstituted or substituted; ! B is —O—, —S— or NH—; ! R1 represents hydrogen; ! R2 is S (O) 2R4 or C (O) (CH2) n-C (O) OR5; ! R3 is halogen, cyano, (CO) OR6 or C (O) NR7R8; ! R4 is unsubstituted or substituted aryl; ! R5 is hydrogen, (C1-C6) alkyl or unsubstituted or substituted aryl; ! R6 represents hydrogen or (C1-C4) alkyl; ! R7 and R8 independently represent hydrogen or (C1-C6) alkyl; ! n is an integer from 1 to 3; and! its stereoisomer, pharmaceutically acceptable salt or solvate. ! 3. The connection according to claim 2, where! Ar is a phenyl group substituted with heterocyclyl, wherein the heterocyclyl group may be unsubstituted or substituted; ! B is —O—; ! R1 represents hydrogen; ! R2 represents S (O) 2R4; !