TRANSGENIC ANIMALS HAVING MAIN ALZHEIMER'S DISEASE-RELATED DISORDERS

摘要

FIELD: medicine.;SUBSTANCE: invention relates to field of genetic engineering and medicine. Described is animal, non-human, having sequence of nucleic acid encoding presenilin 1, carrying mutations, corresponding to M233T and L235P mutations in PS1 protein of mouse. Animal also contains sequence of nucleic acid, encoding whole gene or part of gene, encoding APP. APP protein represents APP751, originates from human and carries mutations Swedish and London. Animal is intended for application in fight against Alzheimer's disease. Also described are PS1 protein and encoding it nucleic acid.;EFFECT: invention can be used in medicine for discovering compounds intended for Alzheimer's disease treatment.;20 cl, 50 dwg, 1 tbl, 8 ex