APPLICATION OF SPHINGOSINE-1-PHOSPHATE (SIP) RECEPTOR AGONISTS FOR TREATMENT OF DEGENERATIVE BRAIN DISEASES

摘要

FIELD: medicine.;SUBSTANCE: claimed are pharmaceutical composition, which contains therapeutically efficient amount of 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol in free form or in form of pharmaceutically acceptable salt for treatment of progressing dementia or degenerative brain diseases and corresponding method of treatment. Demonstrated is inhibition by compound of monocyte chemotaxis, caused by β-amyloid protein in addition to agonistic activity to SIP receptor.;EFFECT: improvement of memory condition in patients with Alzheimer's disease.;7 cl, 2 tbl