THYROID GLAND FOLLICULAR CELL PROLIFERATION STIMULATING OLIGOPEPTIDE

摘要

FIELD: chemistry; biochemistry.;SUBSTANCE: invention relates to biotechnology and specifically to biologically active substances of peptide nature which modulate activity of certain growth factors relative stimulation of proliferation of thyroxine producing follicular cells of the thyroid gland. The invention can be used in medicine and experimental biochemistry. Proteins which are highly homologous to the thyrotropic hormone are sought for. After that a functional TSH site is built up in silico based on the spatial structure of the complex of the β2 adrenoceptor/antibody to the β2 adrenoreceptor taking into account homology of the TSH and antibodies to the β2 adrenoreceptor. Chemical synthesis of the identified amino acid residues of antibodies to the β2 adrenoreceptor is then carried out. Further, the synthesised oligopeptides are biologically tested. The said oligopeptide has general formula X1-X2-X3 (I), where X1 is Trp or Tyr; X2 is Gly, Gin, Glu, or Asp, X3 is Tyr or Trp.;EFFECT: invention widens the range of biologically active substances of peptide nature.;2 dwg, 1 tbl, 4 ex