METHOD OF CORRECTING ENDOTHELIAL DYSFUNCTION WITH AZITHROMYCIN IN MODELING OF CHRONIC GRAM-POSITIVE SEPSIS

摘要

FIELD: medicine.;SUBSTANCE: for correction of endothelial dysfunction in experiment on rats dysfunction is modelled by preliminary sensitisation of animal with staphylococcus anatoxin in doze 0.1 ml subcutaneously. Then after 24 hours in the same place as anatoxin introduced is suspension of Staphylococcus aureus subcutaneously in dose 60 billions of microbial bodies in 1 ml. After that for following generalisation of infectious agent, daily massage of injection place is carried out. At this background introduced is macrolidal medication azithromycin intragastrically in dose 30 mg/kg/day.;EFFECT: method ensures activation of endothelial dysfunction correction.;1 ex, 1 tbl