Colloidal nanoparticle carriers containing charged or unladen water-soluble camouflages and their use for mucosal applications

摘要

The use of a colloidal nanoparticulate carrier (A) containing at least one water-soluble comb polymer (I) for mucosal application is claimed. An Independent claim is also included for a colloidal nanoparticulate carrier (A') containing a backbone formed from water-soluble polyol(s) and hydrophobic side-chains, providing an amphiphilic character, and optionally ionic groups, where the backbone polymer has a weight average molecular weight (Mw) of 10000-30000 (preferably 15000-25000, especially 20000) and the side-chains preferably have a combined Mw of 45000-100000 (especially 50000-80000, particularly 50000-60000).