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cell therapy for chronic stroke

机译:慢性中风的细胞疗法

摘要

A method of treating stroke in a patient who has undergone a stroke comprising administering at least 2 million suitable neuronal cells to at least one brain area involved in the stroke. The method comprises the step of using a twist drill or a burr to form a hole in the skull through which the cells could be administered. Exemplary cells are hNT neuronal cells, HCN-1 cells, fetal pig cells, neural crest cells, neural stem cells, or a combination thereof. Also disclosed herein is a pharmaceutical composition of 95 % pure hNT neuronal cells, which composition further includes a vial containing PBS and human neuronal cells. This vial is provided in a container with liquid nitrogen, whereby the composition is frozen and maintained at -170 DEG C before use. Also disclosed are methods of improving speech, cognitive, sensory, and motor function in a person who has experienced brain damage which interferes with function by administering a sterile composition of a sufficient number of neuronal cells or neural stem cells to the damaged area. Also disclosed is a method of replacing central nervous cells lost to neurodegenerative disease, trauma, ischemia or poisoning.
机译:一种在已中风的患者中治疗中风的方法,该方法包括将至少2百万个合适的神经元细胞施用于中风涉及的至少一个脑区域。该方法包括使用麻花钻或毛刺在颅骨上形成孔的步骤,通过该孔可以施用细胞。示例性细胞是hNT神经元细胞,HCN-1细胞,胎猪细胞,神经rest细胞,神经干细胞或其组合。本文还公开了95%纯hNT神经元细胞的药物组合物,该组合物还包括含有PBS和人神经元细胞的小瓶。该小瓶装在装有液氮的容器中,由此在使用前将组合物冷冻并保持在-170℃。还公开了通过对受损区域施用足够数量的神经元细胞或神经干细胞的无菌组合物来改善遭受脑损伤的人的言语,认知,感觉和运动功能的方法,所述脑损伤会干扰功能。还公开了一种替代因神经退行性疾病,创伤,局部缺血或中毒而丧失的中枢神经细胞的方法。

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