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SUMMARIES FOR IMPROVING ANTI-ISENSE EFFICIENCY AND TRANSPORTING NUCLEAR ANALOGY IN CELLS
SUMMARIES FOR IMPROVING ANTI-ISENSE EFFICIENCY AND TRANSPORTING NUCLEAR ANALOGY IN CELLS
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机译:改善细胞的反义效率和运输核类似物的摘要
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摘要
Compositions and methods for enhancing delivery of molecules, e.g. biological agents, into cells are described. The composition is a conjugate of the biological agent, preferably a nucleic acid analog having a substantially uncharged backbone, covalently linked to a peptide transporter moiety as described. Conjugation of the peptide transporter to a substantially uncharged nucleic acid analog, such as a morpholino oligomer, is also shown to enhance binding of the oligomer to its target sequence and enhance antisense activity.
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