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conjugates of angiotensin peptide analogues and chelating agents for diagnosis and therapy
conjugates of angiotensin peptide analogues and chelating agents for diagnosis and therapy
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机译:血管紧张素肽类似物和螯合剂的结合物用于诊断和治疗
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摘要
A pharmaceutical of the general formula Z(L)n-V, wherein V denotes an amino acid sequence X1-X2-Val-Tyr-Ile-His-Pro-X8-X9-X10; L denotes a bond or a linker; Z denotes a group that optionally can carry an imaging moiety M; X1 denotes an amino acid; X2 denotes Arg or N-alkylated Arg or a mimetic of Arg; X8, X9 and X10 constitute an ACE cleavage site; Z forms a bond with the amino acid X1 optionally through the linker L; and M where denotes an imageable moiety capable of detection either directly or indirectly in a diagnostic imaging procedure.
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机译:通式Z(L)n-V的药物,其中V表示氨基酸序列X1-X2-Val-Tyr-Ile-His-Pro-X8-X9-X10; L表示键或连接基; Z表示任选地可以带有成像部分M的基团; X1表示氨基酸; X 2表示Arg或N-烷基化的Arg或模拟的Arg; X8,X9和X10构成ACE切割位点; Z任选地通过接头L与氨基酸X1形成键; M表示可在诊断成像过程中直接或间接检测的可成像部分。
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