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SYNTHETIC ANALOGUES OF PHOSPHATIDYL-MYO-INOSITOL MANNOSIDES WITH ACTIVE INHIBITOR OF INFLAMMATORY RESPONSE

机译:具有炎症反应活性抑制剂的磷脂酰肌醇甘露糖苷的合成类似物

摘要

The present invention relates to novel synthetic analogs of phosphatidyl-myo-inositol mannosides (hereinafter PIM) general formula (I): ## EQU1 ## -format = "tif" / or a pharmaceutically acceptable salt thereof, process for their preparation and their use in the prevention or treatment of a disease associated with overexpression of cytokines or chemokines, in particular TNF and / or IL-12. The invention also relates to a pharmaceutical composition comprising at least one synthetic derivative of PIM.
机译:本发明涉及磷脂酰肌醇甘露糖苷(以下称为PIM)通式(I)的新型合成类似物:制备其的方法或其药学上可接受的盐。及其在预防或治疗与细胞因子或趋化因子特别是TNF和/或IL-12过度表达有关的疾病中的用途。本发明还涉及包含至少一种PIM的合成衍生物的药物组合物。

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