N-substituted amidoxime derivatives for the prophylaxis and/or treatment of tropical diseases

摘要

N-substituted amidoxime derivatives for the prophylaxis and/or treatment of tropical diseases N-substituted amidoxime derivatives of formula (I) wherein R1is a substituent ; V, W and X are independently C-R2or N, with the proviso that at least one of V, W and X is C-R2; R2is independently hydrogen, alkyl, halogen, -CH2R3, -OR4, -SR4or aryl; and R3and R4are substitutents. Compositions comprising N-substituted amidoxime derivatives, processes for their preparation and their use as pharmaceutically active agents in the prophylaxis and/or treatment of tropical diseases caused by leishmania, trypanosome, protozoa and plasmodium falciparum such as South American trypanosomiasis, African trypanosomiasis, sleeping sickness, Kala-Azar, visceral leishmaniasis, Bagdad boil or Aleppo boil, cutaneous leishmaniasis, espundia, Chagas disease, mucocutaneous leishmaniasis, trichomoniasis, urogential trichomonosis, giardiasis, lamblia dysentery, amoebiasis, primary amebic meningoencephalitis, keratitis or meningitis, coccidiosis, sarcosporidosis, toxoplasmosis, malaria tropica, malaria tertian, malaria quartana, pneumocystis carinii, pneumonia, pneumocystosis, Balantidium dystentery and oriental sore are also outlined.