TRANSGENIC MOUSE HAVING HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) PHENOTYPE, EXPERIMENTAL USE AND APPLICATION

摘要

PPROBLEM TO BE SOLVED: To provide a transgenic mouse having human major histocompatibility complex phenotype and a cell. PSOLUTION: The present invention relates to transgenic mice, isolated transgenic mouse cells, and methods of using the mouse, the mice and mouse cells comprising a disrupted H2 class I gene, a disrupted H2 class II gene, a functional HLA class I transgene, and a functional HLA class II transgene. In embodiments, the transgenic mouse or mouse cells are deficient for both H2 class I and class II molecules, wherein the transgenic mouse comprises a functional HLA class I transgene and a functional HLA class II transgene. In embodiments, the transgenic mouse or mouse cell has the genotype HLA-A2SP+/SPHLA-DR1SP+/SP2m IA. PCOPYRIGHT: (C)2011,JPO&INPIT