METHODS FOR PRODUCING SYNTHETIC SURFACES THAT MIMIC COLLAGEN COATED SURFACES FOR CELL CULTURE AND CULTURED SURFACES PREPARED BY SUCH METHOD

摘要

PROBLEM TO BE SOLVED: To provide methods for producing synthetic surfaces that mimic the collagen coated surfaces for cell culture not only reduce the cost and/or issues associated with animal-derived collagen but are also amenable to large scale manufacturing.;SOLUTION: The methods comprises: providing a monomer source comprising one or more organic compounds which are capable of polymerization, wherein at least one organic compound is prolinol; creating a plasma of the monomer source; and contacting at least a portion of the surface with the plasma to provide a plasma coated surface. Such methods provide an animal-free, synthetic, chemically defined surface that mimics a collagen coated surface for cell culture. Such methods not only reduce the cost and/or issues associated with animal-derived collagen but are also amenable to large scale manufacturing.;COPYRIGHT: (C)2011,JPO&INPIT