METHOD FOR DETERMINING AFFECTION RISK OF ARTERIOSCLEROTIC DISEASE OF DIABETIC PATIENT AND TEST AGENT THEREFOR

摘要

PROBLEM TO BE SOLVED: To provide a gene and genetic polymorphism associated with occurrence risk of arteriosclerotic diseases of a diabetic patient, a method for determining the latent risk (affection risk) to develop arteriosclerotic diseases, especially atherosclerosis and myocardial infarction on individual diabetic patients based on the information on the gene, etc., especially the number of oxidation promoting alleles, and a reagent and a reagent kit useful for easily performing the method.SOLUTION: The level of the affection risk of arteriosclerotic diseases is determined by detecting (1) genetic polymorphism (GCLM C-588T) at position -588 of GCLM gene, (2) genetic polymorphism (MPO G-463A) at position -463 of MPO gene, (3) genetic polymorphism (PON 1 Gln192Arg) of PON1 gene and (4) genetic polymorphism (CYBA C242T) at position 242 of CYBA gene on a biospecimen of a diabetic patient, and determining the level based on the number of oxidation promoting alleles held by the polymorphisms.