MECHANISM-BASED TARGETED PANCREATIC beta-CELL IMAGING AND THERAPY

摘要

PPROBLEM TO BE SOLVED: To provide a composition and a method for imaging -cells in vivo, and a composition and a method for improving diagnosis and treatment of pancreas-associated diseases based on finding the delivery of a pharmaceutical agent having therapeutic value specific to pancreatic -cells. PSOLUTION: The composition for imaging the -cells includes a chelating agent-antidiabetic agent conjugate and, if needed, a metal to be chelated. The composition for imaging the pancreas including the antidiabetic agent, the chelating agent and a metal ion to be chelated are disclosed. The method for treating the pancreas is also disclosed. The method includes a process for administering the composition including the antidiabetic agent, the chelating agent and the metal ion to be chelated to subjects requiring the treatment of pancreatic diseases. In the composition, the metal ion is a -ray emitter. PCOPYRIGHT: (C)2011,JPO&INPIT