COMBINATION OF 5-HETEROCYCLIC RING-SUBSTITUTED IMINO-9-DIALKYLAMINOBENZOA PHENOXATHIIN COMPOUND OR SALT THEREOF AND ARTEMISININ DERIVATIVE FOR PREVENTION OR TREATMENT OF MALARIA PLASMODIUM SPECIES DISEASE

摘要

PPROBLEM TO BE SOLVED: To provide a disease prevention or a treatment for a new strain of malaria Plasmodium having a highly therapeutic effect and selective toxicity toward malaria Plasmodium-based infectious disease and capable of suppressing the emergence of a resistant malaria Plasmodium strain as compared with a case of administering an active ingredient in a monotherapy. PSOLUTION: As an active ingredient, 5-heterocyclic ring-substituted imino-9-dialkyl aminobenzo[a]phenoxathiin compound or its salt shown by Formula (I) and an artemisinin derivative are combined. In the formula, RSP1/SPand RSP2/SPare each independently a methyl group, ethyl group, propyl group, 2-hydroxyethyl group or 2-methanesulfoneamideethyl group; RSP3/SPrepresents a 2-pyridyl group or 4-pyridyl group; RSP4/SPrepresents a fluorine atom, chlorine atom, methoxy group or methyl group; RSP5/SPis a fluorine atom, chlorine atom, methoxy group or methyl group; m represents an integer of 0 or 1; n represents an integer of 0 or 1; and an negative ion represented by XSP-/SPis a chlorine atom, bromine atom, nitric acid ion, sulfonic acid ion, p-toluenesulfonic acid ion or oxalic acid ion. PCOPYRIGHT: (C)2011,JPO&INPIT