B CELL-MEDIATED VACCINE LOADED WITH LIGAND OF NATURAL KILLER T CELL AND ANTIGEN

摘要

PPROBLEM TO BE SOLVED: To provide an immune prophylaxis and prophylactic vaccine containing B cells mediated by -galactosylceramide, a kind of glycolipid and a ligand of a natural killer T cell. PSOLUTION: B cells, which are easily obtainable compared with dendritic cells, not only induce a similar level of cytotoxic T lymphocyte response to that of the conventional dendritic cell-based vaccine but also have a prophylactic and therapeutic effect on subcutaneous cancer and metastatic cancer. Thus, the B cell-mediated vaccine composition can be used as an antitumor immunotherapeutic agent. PCOPYRIGHT: (C)2011,JPO&INPIT