首页> 外国专利> Novel {4- 2- (dimethylamino) -1- (1-hydroxycyclohexyl) ethyl phenoxy} phosphate or a pharmaceutically acceptable salt thereof, a process for producing the same, and a central nervous system containing the same as an active ingredient Pharmaceutical composition for prevention and treatment of disease

Novel {4- 2- (dimethylamino) -1- (1-hydroxycyclohexyl) ethyl phenoxy} phosphate or a pharmaceutically acceptable salt thereof, a process for producing the same, and a central nervous system containing the same as an active ingredient Pharmaceutical composition for prevention and treatment of disease

机译:新型{4- [2-(二甲基氨基)-1-(1-羟基环己基)乙基]苯氧基}磷酸酯或其药学上可接受的盐,其制备方法和包含其作为有效成分的中枢神经系统疾病防治组合物

摘要

The present invention relates to a novel {4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenoxy}phosphate or a pharmaceutically acceptable salt thereof, a production method therefor and a pharmaceutical composition for preventing and treating central nervous system disorders which contains the same as an active component. The novel {4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenoxy}phosphate or a pharmaceutically acceptable salt thereof according to the present invention can beneficially be used to prevent and treat central nervous system disorders since it exhibits an equivalent biological and pharmacological activity to venlafaxine and salts thereof which are known in the field, it has very little toxicity, and, in particular, it is outstandingly soluble in water as compared with prior-art venlafaxine derivatives.
机译:本发明涉及新型{4- [2-(二甲基氨基)-1-(1-羟基环己基)乙基]苯氧基}磷酸酯或其药学上可接受的盐,其制备方法和用于预防和治疗中枢神经的药物组合物。包含与活性成分相同的系统疾病。根据本发明的新型{4- [2-(二甲基氨基)-1-(1-羟基环己基)乙基]苯氧基}磷酸酯或其药学上可接受的盐可有益地用于预防和治疗中枢神经系统疾病与本领域已知的文拉法辛及其盐具有同等的生物学和药理活性,其毒性很小,特别是与现有技术的文拉法辛衍生物相比,其在水中的溶解性极好。

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