THIAZOLE DERIVATIVE HAVING CB1-ANTAGONISTIC, AGONISTIC OR PARTIAL AGONISTIC ACTIVITY

摘要

PPROBLEM TO BE SOLVED: To provide a thiazole derivative which is a powerful cannabinoid (CBSB1/SB) receptor antagonist, a powerful cannabinoid (CBSB1/SB) receptor agonist or a powerful cannabinoid (CBSB1/SB) receptor partial agonist and exhibits benefits for treating psychiatric disorders, neurological disorders, and other diseases relating to cannabinoid CBSB1/SBneurotransmission. PSOLUTION: The thiazole derivative is represented by formula (1), wherein R is a halogen atom and each of RSB1/SBto RSB4/SBis a specified substituent. PCOPYRIGHT: (C)2011,JPO&INPIT