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Herpes simplex virus (HSV) with modified affinity, methods of use and preparation thereof
Herpes simplex virus (HSV) with modified affinity, methods of use and preparation thereof
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机译:具有修饰的亲和力的单纯疱疹病毒(HSV),其使用方法和制备
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摘要
A modified Herpes Simplex Virus (HSV), which has a portion of gD (glycoprotein D) of the glycoproteic envelope deleted and a heterologous single chain antibody inserted in place of such deleted portion; the modified HSV is capable of infecting cells through receptor HER2/ErbB2 but not through receptors HVEM/HveA and nectin1/HveC; uses of the modified HSV and a process of the preparation thereof are also disclosed.
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