METHOD FOR PREPARING SILICIC ACID-CONTAINING EXTRUDATE, EXTRUDATE, USE OF EXTRUDATE, AND PHARMACEUTICAL COMPOSITION COMPRISING EXTRUDATE

摘要

PROBLEM TO BE SOLVED: To formulate a bioavailable, solid galenic formulation of silicic acid stabilized with quaternary ammonium compounds such as choline chloride, or an amino acid source.;SOLUTION: The invention relates to a method for preparing a silicic acid-containing extrudate comprising the steps of: (i) forming stabilized silicic acid by hydrolyzing a silicon compound into orthosilicic acid and/or oligomers thereof in the presence of a stabilizing agent, which is a quaternary ammonium compound, or an amino-acid, or an amino acid source or combinations thereof; (ii) mixing the stabilized silicic acid with a carrier in an amount up to the loading capacity of the carrier for the silicic acid; and (iii) extruding the resulting mixture thereby forming the extrudate, to an extrudate obtainable with the method, to uses of the extrudate for the production of animal feed, feed supplement, human food and/or food supplement and for a pharmaceutical or cosmetic preparation, and for the treatment of infections, nails, hair, skin, teeth, collagen, connective tissue, bones, cell generation and degenerative (ageing) processes, and to a pharmaceutical composition comprising the extrudate.;COPYRIGHT: (C)2011,JPO&INPIT