METHODS AND COMPOSITIONS FOR THE CORRELATION OF SINGLE NUCLEOTIDE POLYMORPHISMS IN VITAMIN K EPOXIDE REDUCTASE GENE AND WARFARIN DOSAGE

摘要

PPROBLEM TO BE SOLVED: To provide a method of identifying a human subject having increased or decreased sensitivity to warfarin. PSOLUTION: The method comprises detecting in the subject the presence of a single nucleotide polymorphism in the Vitamin K epoxide reductase (VKOR) gene, wherein the single nucleotide polymorphism is correlated with increased or decreased sensitivity to warfarin, thereby identifying the subject having increased or decreased sensitivity to warfarin. PCOPYRIGHT: (C)2011,JPO&INPIT