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Membrane translocation peptide, compositions containing the peptide, used in the preparation of formulations of the pharmaceutical formulations and the peptide containing the same peptide
Membrane translocation peptide, compositions containing the peptide, used in the preparation of formulations of the pharmaceutical formulations and the peptide containing the same peptide
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机译:膜易位肽,包含该肽的组合物,用于制备药物制剂的制剂以及包含相同肽的肽
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摘要
The present invention relates to a novel membrane translocating full-length peptide sequence, fragment, motif, derivative, analog or peptidomimetic thereof (MTLPs), to nucleotide sequences coding therefor, and to compositions comprising a MTLP-active agent complex and a MTLP-active particle complex. The MTLP or the nucleotide sequence coding therefor enhance movement of the active agent or of the active particle across a lipid membrane. More particularly, the present invention relates to an MTLP-active agent complex and an MTLP-active particle complex, wherein the MTLP enhances uptake of the active agent into a cell, into or out of an intracellular compartment and across a cell layer. Methods of making and methods of using MTLPs also are included.
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