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Improved peptides, immunogenic compositions and vaccines or pharmaceutical formulations, methods of immunizing animals against LHRH hormones, and LHRH tandem repeat peptides and their use as vaccines
Improved peptides, immunogenic compositions and vaccines or pharmaceutical formulations, methods of immunizing animals against LHRH hormones, and LHRH tandem repeat peptides and their use as vaccines
The invention relates to a modified tandem LHRH-peptide vaccine preparation in which the amino acid glycine at position (6) of one or both LHRH decapeptides that constitute the tandem unit is substituted by a dextrorotatory amino acid that contains a side chain to which a carrier compound can be coupled. In addition, the tandem LHRH-peptide can be brought into a tandem-dimer form which is also suitable for producing a vaccine that is effective against LHRH (luteinizing hormone releasing hormone) also referred to as GnRH (gonadotropin-releasing hormone), for immunological castration, to inhibit or affect reproductive functions or to affect behaviour in vertebrates in general and in domesticated animals and man in particular.
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