PHARMACEUTICAL COMPOSITION FOR THE PREVENTION AND TREATMENT OF β AMYLOID IN THE BRAIN CONTAINING GCPII (GLUTAMATE CARBOXYPEPTIDASE-II) AS ACTIVE INGREDIENT AND COMPOSITION FOR SCREENING THERAPEUTIC AGENT AND SCREENING METHOD USING THE SAME

摘要

The present invention relates to a pharmaceutical composition for the prevention and treatment for -amyloid (A) accumulation in brain comprising GCP-II (Glutamate carboxypeptidase-II) as an active ingredient, a composition for screening method of the same. GCP-II of the present invention not only degrades A monomer and oligomer but also degrades soluble A and insoluble A, particularly aggregated A, so that it can prevent the accumulation of A in brain or reduce the accumulation, making it an excellent candidate for the therapeutic agent for Alzheimer's disease and Down's syndrome.