- - Pharmaceutical composition and composition for screening therapeutics to preventing and treating of -amyloid accumulation in brain comprising GCP-Glutamate carboxypeptidase- as an active ingredient method for screening using said composition

摘要

The present invention relates to a pharmaceutical composition for preventing and treating accumulation in the brain of β-amyloid (Aβ) containing GCP-II as an active ingredient, a composition for screening a therapeutic agent, and a screening method using the same. -II has the effect of decomposing not only monomeric and oligomeric forms of Aβ, but also soluble and insoluble forms, and Aβ converted to aggregated forms, thereby preventing or eliminating Aβ from accumulating in the brain, resulting in Alzheimer's disease and It can be used to treat diseases such as syndrome.